Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan. Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei 110, Taiwan. Department of Anatomy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Camillian Saint Mary's Hospital Luodong,160 Zhongzheng S. Rd. Luodong, Yilan 26546, Taiwan. Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Department of Basic Medical Science, Center for Transitional Medicine, Xiamen Medical College, Xiamen 361023, China.